Diamino-chlorophenyl-ethylpyrimidine

CHLOROPHENYL)-5-((4-CHLOROPHENYL)XETHOXY)-4-IODO-3(2H)-PYRIDAZINONE see CJT800 (2-CHLOROPHENYL)-a-(4-CHLOROPHENYL)-5-PYRIMIDINEMETHANOL see FAKIOO a-(2-CHLOROPHENYL)-a-(4-CHLOROPHENYL)-5-PYRIMIDINEMETHANOL see FAKIOO 5-(4 -CHLOROPHENYL)-2,4-DIAMINO-6-ETHYLPYRIMIDINE see TGDOOO (o-CHLOROPHENYL)(3-(2,4-DICHLOROPHENOXY)-... 

Pyrimethamine Pyrimethamine, 2,4-diamino-5-(4 -chlorophenyl)-6-ethylpyrimidine (33.1.60), is synthesized from 4-chlorobenzycyanide, which upon condensation with methyl ester of propionic acid in the presence of sodium methoxide gives the 8-ketonitrile... 

DIAMINO-5-p-CHLOROPHENYL-6-ETHYLPYRIMIDINE see TGDOOO DI(-4-AMINO-3-CHLOROPHENYL)METHANE see MJM200... 

Pyrimethamine [2,4-diamino-5-(p-chlorophenyl)-6-ethylpyrimidine] is most active against protozoal dihydrofolate reductase. However, there is only a small margin between the dose required to kill the organisms and that which will affect the host. It is most commonly used in the treatment of toxoplasmosis hut more recently has heen used at a lower and safer dose of 25 mg weekly for malarial prophylaxis. This dose is unlikely to produce any adverse hematological complications in the short term. Larger doses are required to treat toxoplasmosis and where it exceeds 25 mg daily a megaloblastic anemia will develop in many of the patients so treated (Nl). 

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