Diamino acid linkers

Unnatural Diamino Acid Derivatives as Scaffolds for Creating Diversity and as Linkers for Simplifying Screening in Chemical Libraries... 

Our interest in diamino acid building blocks or scaffolds is connected with the studies of a new type of safety-catch linkers based on a dia-mino acid residue that we have carried out. Safety-catch linkers for... 

The BAP functional monomer was prepared by 2,6-diamino pyridine and acryloyl chloride in triethylamine-chloroform solution (54% yield) [37]. Cyclobarbital-imprinted copolymers were prepared by the following procedure BAP (Immol), template cyclobarbital (0.5 mmol) and EGDA cross-linker (20 mmol) were dissolved in CHCI3. In the presence of a radical initiator, 2,2-azo (2,4-dimethylvaleronitrile), radical copolymerization was performed in N2 atmosphere with a two-step process for 6 h at 40°C and then for 3 h at 90°C. The obtained polymer was ground and sieved in the range of 26-63 pm. Selectivity of the cyclobarbital-imprinted polymer was assessed by chromatographic analysis for 5-barbiturates. They also used BAP monomer to imprint antitumor active compound of 5-fluorouracil (5-FU) [36]. The 5-FU imprinted polymers showed a higher afihnity for 5-FU than for 5-FU derivatives. The BAP imprinted polymer was prepared in the presence of a co-monomer, 2-(trifluoromethyl)-acrylic acid. 

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