Diagnosis of Anaphylaxis to Neuromuscular Blocking Drugs

The tryptase test is discussed in detail in Sect. 4.5.1 where details of the assays for total and mature tryptase are given. 

Eor a detailed discussion of the employment of skin testing in the diagnosis of drug allergy, the reader is referred to Sect. 4.2. 

Skin testing of patients who experienced a suspected immediate allergic reactiou to an NMBD should be undertaken no earher than 4-6 weeks after the reaction. Since most of the IgE antibodies may have been consumed during the allergic event, testing within the 4-6 week period increases the risk of a false-positive finding, so only positive results should be taken notice of and a negative test should be repeated after the 

7 Drugs and Other Agents Used in Anesthesia and Surgery 

Data from Mertes PM et al. J Invest AUergol Clin Immunol 2011 21 442 

---

Fisher MM, Baldo BA. Immunoassays in the diagnosis of anaphylaxis to neuromuscular blocking drugs the value of morphine for the detection of IgE antibodies in allergic subjects. Anaesth Intensive Care 2000 28(2) I67-70. 

---