Diacetylene glycolipids

X, Y Synthesis and Self-Assembling Properties of Diacetylene-Containing Glycolipids (from Nie and Wang, 2006)... 

Glycolipid incorporated liposomes have found extensive use as sensors for the detection of Escherichia coli bacteria. Liposomes prepared using a diacetylene and a glucosyl lipid underwent a chromatic transition upon the addition of E. coli (Ma et al. 1998). The chromatic transition is sensitive to the diyne and glycolipid stmc-ture (Ma et al. 2000). An optimized vesicle assembly, consisting of a maltotriosyl lipid, phospholipid, and diyne, detected E. coli at a concentration of 2x10 cells/mL... 

Figure 10 Self-assembled nanotubes can be obtained through a rolling mechanism (chiral molecular packing) or packing directly from the monomer. The structures of amphiphilic molecules used in nanotube formation (a) diacetylenic phospholipids, (b) diacetylenic N-aldonamides, (c, d, and e) glucose glycolipids, (f) sphingolipids, (g) glucophospholipid amphiphiles, (h) amphiphile with a serine head. R and R groups represent a variety of alkyl, alkenyl, or alkynyl groups. (Reproduced with permission from Ref. 52. The Chemical...

Incorporation of diacetylenic fatty acids into biomembrane phospho- and glycolipids has been accomplished with the bacterium. 

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