Di thiocarboxylation

Other successful sulfuration agents are (di)thiocarboxylic acids or dithiophosphoric acid esters (87JAP62-10081). 

Third in importance are the S-glucuro-nides formed from aliphatic and aromatic thiols (reaction 12 in Fig. 13.21) and from di-thiocarboxylic acids (reaction 13) such as di-ethyldithiocarbamic acid, a metabolite of dis-ulfiram. As for C-glucuronidation (reaction 14), this reaction has been seen in humans for 1,3-dicarbonyl drugs such as phenylbutazone and sulfinpyrazone (28) (Fig. 13.23). 

Di)thiocarboxylic acids -COSH, -CSSH (Di)thiocarboxy... -carbo(di)thioic S-acid ... 

Bis(thiocarboxylato) niobium 18Nb(RCOS)2 [207] and bis(r] -cyclopenta-di-enyl)bis(thiobenzoato)niobium 19 [110] have been synthesized by stoichiometric reactions of NbCl2 with sodium thiocarboxylates and of Nb(Cp)2X2 (X=C1, Br, I) with thallium thiobenzoate, respectively. The structure of 19 is considered to be analogous to the tantalum complex 20, in which the thiocar-boxylato ligands are monodentate through the sulfur atom [110]. 

Special thiol carboxylic esters (29) were prepared fiom aroyl halides and arene thiolates. These 4,4 -disubstituted S-aiyl arenecarbothioates might gain importance hrtnn a practical point of view, since they exhibit liquid crystal properties and could be useful as components of a di lay cell. Another thiocarboxylic ester (30), which was obtained from a zinc thiochelate and benzoyl chloride (equation 19), might be potentiaUy useful as a precursor for organic conductors. 

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