Di-n-Butyltin Chloride DBTC

like TBTC, appears to interfere with the function of ATP synthase. Table 4.5.3 indicates the decreases in ATP levels that occurred when NK cells were exposed to DBTC. These decreases did not 

Effects on Mitogen-Activated Protein Kinase (MAPK) Activity 

In preliminary experiments, we have shown that DBTC exposure, like TBTC, is able to increase the activation of MAPK. The activations of the MAPK, p44/42, seen with DBTC appear to be less intense than those seen with TBTC, while the activations of p38 and INK seem to be similar to those seen with TBTC. 

4 Effects of Trimethyltin Chloride (TMTC) on Human NK Cell Function 

The following series of triorganotins differ significantly in their hydrophobicity trimethyltin dimethylphenyltin methyldiphenyltin triphenyltin. Thus, the role of the lipophilic nature of organ-otin compounds in their capacity to interfere with NK function could begin to be examined using this series of compounds. 

---