DHFR-trimetrexate complex

Fig. 26. Stereoview of a superposition over the backbone atoms (N, CQ and C) of residues 1-162 of the final 22 structures of the DHFR-trimetrexate complex, (a) View of the protein backbone and the trimetrexate heavy atoms, (b) View of trimetrexate in the binding site of enzyme, (c) Conformation of trimetrexate in the binding site of enzyme. The orientation of trimetrexate is identical for all three figures (a)-(c) and only its heavy atoms are shown. (Reproduced from Polshakov et a/.146 with permission. Copyright (1999) The Protein Society, Cambridge University Press.)...

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