DHAP acyltransferase

ALDP, DHAP, dihydroxyacetone phosphate DHAPAT, dihydroxyacetone phosphate acyltransferase NALD, neonatal adrenoleukodystrophy RCDP, rhizomelic chondrodysplasia punctata X-ALD, X-linked adrenoleukodystrophy ZS, Zellweger s syndrome. 

Fig. 5. Biosynthesis of membrane phospholipids from alkyldihydroxyacetone-P (alkyl-DHAP), the first detectable intermediate formed in the biosynthetic pathway for ether-linked glycerolipids. Enzymes catalyzing the reactions are (1) NADPH alkyl-DHAP oxidoreductase, (II) acyl-CoA 1 -alkyl-2-lyso-sn-glycero-3-phosphate acyltransferase, (III) l-alkyl-2-acyl-in-glycero-3-phosphate phosphohydrolase, (IV) ATP 1-alkyl- /i-glycerol phosphotransferase, (V) CDP-choline l-alkyl-2-acyl-sn-glycerol cholinephosphotransferase (dithiothreitol-sensitive), (VI) CDP-ethanolamine l-alkyl-2-acyI-sn-glycerol ethanolaminephosphotransferase, and (VII) acyl-CoA 1 -alkyl-2-acy 1-OT-glycerol acyltransferase.

CDP-choline (CDP-ethanolamine) choline (ethanolamine) phosphottansferase, are localized in the endoplasmic reticulum. The acylation of dihydroxyacetone phosphate (DHAP) by acyl-coenzyme A (acyl-CoA) is catalysed by dihydroxyacetone phosphate acyltransferase with formation of... 

Figure 2. Biosynthesis of plasmalogens in mammalian tissues. Enzymes (1) dihydroxyacetone phosphate acyltransferase (2) 1-acyldihydroxyacetone phosphate synthase (3) 1-alkyldihydroxyacetone phosphate oxidoreductase (4) l-alkyl-5n-glycero-3-phosphate acyltransferase (5) 1-afkyl 2-acyl-5w-glycero-3-phosphohydrolase (6) CDP-ethanolamine transferase (7) l-alkyl-2-acyl-5w-glycero-3-phosphoethanolamine desaturase (8) methyltransferases and base-exchange enzymes. CDP-ethanolamine, cytidine diphosphoethanolamine. CMP, cytidine monophosphate. CoA, coenzyme A. DHAP, dihydroxyacetone phosphate. NADH, nicotinamide adenine dinucleotide, reduced form. NAD, nicotinamide adenine dinucleotide, oxidized form. Pi, phosphate.

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