Dextran diglycidyl ether

An example of the use of 1,4-butanediol diglycidyl ether for the activation of soluble dex-tran polymers is given in Chapter 25, Section 2.3. One end of the fezs-epoxide reacts with the hydroxylic sugar residues of dextran to form ether linkages, which terminate in epoxy functionalities. The epoxides of the activated derivative then can be used to couple additional mol-ecules-containing nucleophilic groups to the dextran backbone. 

Modification of dextran polymers with 1,4-butanediol diglycidyl ether results in ether derivatives of the dextran hydroxyl groups, which then contain hydrophilic spacers with terminal epoxy functions (Figure 25.16). 

Figure 25.16 An epoxy-functional dextran derivative may be prepared by the reaction of 1,4-butanediol diglycidyl ether with the hydroxyl groups of the polymer.

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