Dextran copolymers

Ferdous, A., Watanabe, H., Akaike, T. and Mamyama, A. (1998) Poly( 1-lysine>graft-dextran copolymer amazing effects on triplex stabilization under physiological pH and ionic conditions (in vitro). Nucleic Acids Res., 26, 3949-3954. 

Natural soft and semi-rigid gels for the separation (A/D agarose-dextran copolymer, D/bA dextran... 

X. Ran, M. Mu, B. Hu, R Yao, and M. Jiang, MicelUzation of easein-graft-dextran copolymer prepared through Maillard reaction, Biopolymers, 81 (2006) 29-38. 

YDE 00] Ydens L, Rutot D., Degee P., et al, Controlled synthesis of poly(epsilon-caprolactone)-grafted dextran copolymers as potential enviromnentally fiiendly surfactants , Macrowo/eca/es, vol. 33, no. 18, pp. 6713-6721,2000. 

PAT Patrizi, M.L., Piantanida, G., Coluzza, C., and Masci, G., ATRP synthesis and association properties of temperature responsive dextran copolymers grafted with poly(A-isopropylacrylamide), Eur. Polym. J., 45, 2779, 2009. 

Ydens I, Degee P, Nouvel C, Dellacherie E, Six JL, Dubois P (2005) Surfactant-free stable nanoparticles from biodegradable and amphiphilic poly(e caprolactone)-grafted dextran copolymers. e-Polymers 46 1-11... 

PLL-g-dextran copolymers with different molecular weights and grafting ratios of dextran side chains were successfully synthesized and characterized by H-NMR. The molecular weights of the selected dextrans were 5.2 and 10 kDa (denoted as dex(5.2) and dex(lO)). Grafting... 

Ferdous, A., Akaike, T., Maruyama, A. Inhibition of sequence-specific protein-DNA interaction and restriction endonuclease cleavage via triplex stabilization by poly(L-lysine)-graft-dextran copolymer. Biomacromolecules 1, 186-193 (2000). doi 10.1021/ bm9900141... 

Synthesis and Structural Features. PLL-g-dextran copolymers with a variety of different architectures (different grafting ratios and lengths of the backbone) were successfully synthesized. Characterization by H-NMR and GPC-MALS was performed to evaluate the grafting ratios and molecular weights, respectively. The detailed structural features of the synthesized copolymers are shown in Table 1. 

Poly(lactide-g-dextran) copolymers were synthesized by a three-step process partial silylation of the dextran hydroxyl groups, ROP of D,L-lactide initiated by the remaining hydroxyl groups of dextran, followed by silyl ether deprotection under mild conditions. The emulsifying properties of these glycopolymers depend on the PLA/dextran ratio [104]. PLA-g-dextran and PLA-g-silylated dextran adopt a core-shell conformation in various solvents [105]. Studies on encapsulation and release behavior of bovine serum albumin from PLA-g-dextran revealed a higher loading than in PLLA microspheres [106]. 

Nouvel, C Dubois, P Sxi, JL. Controlled synthesis of amphiphilic biodegradable polylactide-grafted dextran copolymers. Journal of Polymer Science Part A Polymer Chemistry, 2004, 42, 2577-2588. 

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