Development Programs at the NCI

Because of these limitations, the NCI in 1989 changed to a rationally designed disease-oriented screening panel incorporating 60 cell lines derived from a variety of different human solid tumors (69). Currently, this cell line screen is a key component of the NCTs comprehensive in vitro and in vivo preclinical screening and drug development program. 

The 3-Cell-Line Prescreen and 60-Cell-Line Screen 

Because over 85% of the compounds submitted for screening are found to have no antiproliferative 

Inventory — 60-Cell-Line Screen 9 In vivo Studies Clinical Trials / 

Although the utility of this method of anticancer drug screening and discovery must still be proved, its potential is great. Conceptually, it is important because it extends the disease-oriented approach, originally envisioned when the 60-cell-line screen was created, to 

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