DESS-MARTIN Oxidizing Reagent

DESS - MARTIN Oxidizing Reagent Oxidation of alcohols to aldehydes or ketones by means of penodinanes. 

The catalytic effects and versatility of cerinm(IV) ammonium nitrate as a single-electron oxidant were recently reviewed (Nair and Deepthi 2007, Maulide et al. 2007). However, it should be kept in mind that this oxidative reagent is very powerful and some sensitive fnnctions are not compatible with it. Particularly, some amines are at least as easily oxidizable as the starting molecule bearing the protected group. Anodic oxidation was proposed as a usefnl alternative (De Lamo Martin et al. 2005). 

TMTt deprotection was performed in extremely careful conditions (1 min stirring at rt, five cycles, extensive washing) to avoid the cleavage of the DES linker oxidation with Dess-Martin reagent was performed successfully to give 3.123 (Fig. 3.44). 

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