Desmethyl tirilazad

Cerebral global transient ischaemia in rats induced a rise in cNOS activity from 62.0 6.1 to 133.3113.3 pmol/min x mg protein and cGMP levels from 459.3149.6 to 1974.11132.1 fmol/mg protein (FernAndez etal. 1997). Pre-treatment with 10 mg desmethyl tirilazad/kg intraperitoneally abolished these increases. 

Desmethyl tirilazad reduced brain nitric oxide synthase activity and cyclic guanosine monophosphate during cerebral global ischaemia in rats (Fernandez et al. 1997). 

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See also in sourсe #XX -- [ ]

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