Descinolone acetonide

The c-21 substituent can in fact be dispensed with entirely. Perhaps because descinolone acetonide (254) predates 244 by better than a decade, the synthetic sequence reported for its preparation is quite complex. Although descinolone (253) could in principle be prepared in a few steps from some currently available starting materials, such as 241, the original synthesis is presented for its heuristic Value. 

Descinolone Acetonide Di flucortolone Flucloronide Fluperolone Acetate... 

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