Deprotometalation Using Alkali Metal-Amidoaluminate Complexes

2 Deprotometalation Using Alkali Metal-Amidoaluminate Complexes 

SCHEME 27.7 (Top) Reaction pathways of the 1,2-addition and DoM reaction of benzonitrile using (MeLi). (Bottom box) TS stmctures in the 1,2-addition and DoM reaction of benzonitrile using Me ZnlNMCjlLi. Eneigy changes and bond lengths at the B3LYP/6-31+G and SVP (Zn) level of theory ate shown in kcaEmol and A, respectively. 

SCHEME 27.8 Two possible stmctures of LBUjAlfTMPlLi and DoM reaction of anisole to afford aluminated arene complex having three alkyl groups on aluminum center. 

It is also reported that the efficient isolation of TMP-free, triisobutyl aluminate complex from a benzamide substrate provides the ratho strong evidence that the dominant active base is the (solvated) i-Bu3Al(TMP)Li complex, while the disproportionation between complexes occurs in the solution [59]. 

Single-step DoM reaction via depiotonation with amido ligand 

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