Deoxyribonucleic reactive metabolites

Metabolic activation has been incorporated into most shortterm j n vjjfro assays, usually by use of a mammalian liver microsomal preparation. Some genotoxicants have to be converted into reactive forms before producing observable effects. Metabolism by oxidative enzymes and formation of electrophilic metabolites that bind covalently to deoxyribonucleic acid (DNA) ( I2,23)... 

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