Deoxyribonucleic acid minor groove

The final example in the table (example 5, Table 6.9) is one of a class of similar cyclizations found in several families of antibiotics. For example, it has been argued that the activity of antibiotics such as Dynemicin A (Figure 6.17) results from initial binding (intercalation) of the antibiotic into the minor groove of deoxyribonucleic acid (DNA Chapter 14) followed by cycloaromatization of the enediyne system to produce a diradical intermediate. The diradical then irreversibly finks to the DNA by hydrogen abstraction, damaging it permanently. 

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