Deoxygenation of hemoglobin

Schematic diagram showing structural changes resulting from oxygenation and deoxygenation of hemoglobin.

CDP5-Bb The kinetics of the deoxygenating of hemoglobin in the blood was studied with the aid of a tubular reactor. [1st Ed. P5-3]... 

The primary event in the molecular pathogenesis of SCD involves polymerization of deoxygenated HbS. Since RBCs are packaged with such a high concentration of hemoglobin (32-34 g/dL, 320 to 340 g/L or 19.9-21 mmol/L), it is important... 

Sickle-cell anemia, as we have noted, occurs in individuals homozygous for the sickle-cell allele of the gene encoding the )3 subunit of hemoglobin. Individuals who receive the sickle-cell allele from only one parent and are thus heterozygous experience a milder condition called sickle-cell trait only about 1% of their erythrocytes become sickled on deoxygenation. These individuals may live completely normal lives if they avoid vigorous exercise or other stresses on the circulatory system. 

Heroin and methadone produced a rapid and dramatic reduction in both respiratory rate and cortical hemoglobin oxygenation, while saline had no effects. The authors suggested that opioid-induced acute deoxygenation of cortical hemoglobin was probably associated with respiratory depression. In one in three subjects, oxygen saturation after intravenous heroin fell rapidly, a finding that has not previously been described in humans. 

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