Deoxyadenosine kinase, properties

Krygier, V. Momparler, R.L. The regulatory properties of deoxyadenosine kinase. Biochim. Biophys. Acta, 161, 578-580 (1968)... 

Drabikowska, A.K. Halec, L. Shugar, D. Purification and properties of adenosine kinase from rat liver separation from deoxyadenosine kinase activity. Z. Naturforsch. C, 40, 34-41 (1985)... 

S Additional information <3, 7> (<3> enzyme exists in different conformational states with different substrate kinetic properties [9] <3> presumably one common nucleoside acceptor site [15] <3> purine deoxynucleo-side activity inseparably associated with deoxycytidine kinase protein [16] <3> several isozymes cytosolic deoxycytidine kinase I and II, plus mitochondrial isozyme [10] <3> multisubstrate enzyme, that also phos-phorylates purine deoxyribonucleotides [9] <7> enzyme has two separate active sites for deoxycytidine and deoxyadenosine activity [22] <3> reacts with both enantiomers of -deoxycytidine, -deoxyguanidine, -deoxyadenosine, and a-D-deoxycytidine is also substrate [31] <3> reacts with both enantiomers of jS-deoxyadenosine, j3-arabinofuranosyl-adenine and jd-deoxyguanine ]34] <3> remarkably relaxed enantioselectivity with respect to cytidine derivatives in p configuration [36] <3> lack of enantioselectivity for D- and L-analogues of cytidine and adenosine [43]) [9, 10, 15, 16, 22, 31, 34, 43]... 

S ATP -I- deoxycytidine <1, 3, 4, 8> (<3> deoxycytidine kinase is a multisubstrate enzyme that also phosphorylates deoxyadenosine, it exists in different conformational states with different substrate kinetic properties... 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

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