2-Deoxy-2-fluoro-D-mannose

Coe and Bessell and coworkers studied the metabolic fates of 2-deoxy-2-fluoro-D-glucose (2DFG) and related compounds by using yeast hexokinase (as a model for mammalian hexokinase), and determined the kinetic constants K and V ) of the Michaelis-Menten equation D-glucose 0.17 (K in mAf)> 1 00 (relative value, D-glucose taken as 1) 2DG 0.59 0.11, 0.85 2DFG 0.19 0.03, 0.50 2-deoxy-2-fluoro-D-mannose (2DFM) 0.41 0.05, 0.85 2-deoxy-2,2-difluoro-D-nraZ>//Jo-hexose... 

The incorporation and metabolism of 2-deoxy-2-fluoro-D-[ H]glucose and -D-[ H]mannose in yeast and chick-embryo cells has been studied. 2-Deoxy-2-fluoro-D-glucose, 2-deoxy-2-fluoro-D-mannose, and their GDP and UDP derivatives were found to interfere with protein (involving that of... 

T. Ido, C.N. Wan, V. Casella, J.S. Fowler, A.P. Wolf, M. Reivich, D.E. Kuhl, Labeled 2-deoxy-D-glucose analogs—F-18-labeled 2-deoxy-2-fluoro- o-glucose, 2-deoxy-2-fluoro- D-mannose and C-14-2-deoxy-2-fluoro- o-glucose, J. Label. Compds Radiopharm. 14 (1978) 175-183. 

Ido, T., Wan, C. N., Casella, V., et al. (1978) Labeled 2-deoxy-D-glucose analogs. Fluorine-18-labeled 2-deoxy-2-fluoro-D-glucose, 2-deoxy-2-fluoro-D-mannose and 14C-2-deoxy-2-fluoro-D-glucose. J Labeled Com. Radiopharm. 14, 175-183. 

The metabolic interconversion of 2-deoxy-2-fluoro-D glucose and 2-deoxy-2-fluoro-D-mannose (and their 6-phosphates) in tumour cells was investigated by F - NMR spectroscopy, and a mannose glucose equilibrium ratio of -4 1 was observed.The conversion of 2-deoxy-2-fluoro-D-galactose into its aluco-isomer via the action of a UDP-galactose epimerase has been observed in vivo in mice by use of F - NMR spectroscopy ... 

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