Deoxy-coformycin

The principal drawback to treatment with vidarabine is the ready deamination by adenosine deaminase, an enzyme widely present in human tissues. Improved therapy is being attempted by simultaneously giving an inhibitor of this enzyme such as /Aro-9-(2-hydroxynon-3-yl)adenine 4,17) which has a little anti-viral action of its own. A more powerful inhibitor of this enzyme, pentostatin (deoxy-coformycin) 4,18) is also under investigation (Agarwal, Spector and Parks, 1977). It remains to be seen whether increasing the survival of vidarabine in this way can improve its therapeutic index which seems to be less than that of acyclovir. 

Coformycin, 2 -deoxy—see Pentostatin Colchicine synthesis, 1, 472 isothiazoles in, 6, 174 Collins reagent as oxidizing agent, 2, 170 Colour... 

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