Deng group synthesis

M. Deng, J. Wu, C.A. Reinhart-King, C.C. Chu, Biodegradable functional polyfester amide)s with pendant hydroxyl functional groups synthesis, characterization, fabrication and in vitro cellular response, Acta Biomater. 7 (2011) 1504—1515. 

The Deng group also applied this type of cinchona-based catalyst to the synthesis of tanikolide, a metabolite with antifungal activity of the marine cyanobacterium Lyngbya... 

The activity of some catalytic systems has been studied. For example, Deng has shown that the synthesis of symmetric ureas from aliphatic or aromatic primary amines and C02 can be promoted by catalytic amounts of CsOH in several ILs [128a], Under the working conditions employed (443 K, 6 MPa C02 pressure), the best activity was shown by the system CsOH/BMImCl, whilst the urea yields (up to 98% within 4h, for N,N -dicyclohexylurea) were shown to depend on the amine used. Aromatic amines, such as aniline or p-methoxyaniline, were less reactive than their aliphatic counterparts and afforded the relevant urea in modest yield (27 and 33%, respectively), but only after long reaction times (36 h). In a later study, the same group showed that the synthesis of disubstituted symmetric ureas (RNH)2CO (R = alkyl) from amines and C02 could be promoted also by catalytic... 

Deng, X., Mayeux, A. and Cai, C. (2002) An efficient convergent synthesis of novel anisotropic adsorbates based on nanometer-sized and tripod-shaped oligophenylenes end-capped with triallylsilyl groups. The Journal of Organic Chemistry, 67, 5279-83. 

In a handful of cases, two CCXIH groups have been activated for the synthesis of biaryls. Larrosa and coworkers reported for the first time the decarboxylative homocoupling of aromatic acids mediated by Pd and Ag [62a]. The reaction makes use of Pd(TFA)j as a catalyst and Ag CO as an additive to afford the desired biaryls in 76-95% yields. The only by-products observed were due to the proto-decarboxylation of the aryl carboxylic acid. Both metals are essential for the reaction, and the role of the Ag salt is not only as the terminal oxidant but also as a mediator of the decarboxylation process. The method is subject to some limitations on the substituents on the benzoic acids. Thus, m- and p-nitrobenzoic acids as well as benzoic acids ortho substituted with F, Br, or MeO failed to give decarboxylative homocoupling products. In all cases, protodecarboxylations to the corresponding arenes were the main products observed. The same problem was reported in the protocol developed by Deng and coworkers, where the best results were obtained with PdCl and PPhj in the presence of Ag COj [62b]. 

Wang Y-Z, Deng X-X, Li L, Li Z-L, Du F-S, Li Z-C (2013) One-pot synthesis of polyamides with various functional side groups via Passerini reaction. Polym Chem 4(3) 444-448... 

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