Dendrons, domino

The design of a first generation domino dendron is based on a molecular adaptor with three functional groups. Two identical functionalities are finked to reporter molecules and the third is attached to a trigger (Fig. 2 1). The cleavage of the trigger, initiates a self-immolative reaction sequence that... 

Fig. 2 I Graphical structure of a first generation domino dendron with a trigger and two tail units. II Graphical structure of a second generation domino dendron with a trigger...

Figures 6a and b support our mechanistic and kinetic characterization of the domino dendron system. The kinetic analysis of G1 and G2 dendrons may serve as a rehable method to characterize other domino dendritic systems. It can also allow a better understanding and evaluation of the kinetic contributions of introducing different substituents on the core benzene ring, and of modifying the linker component of the triggering substrate.

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