Dendronized Supports for Multivalent Molecular Recognition

Glycoside-decorated amino-ether dendrons of up to third generation were prepared in solution and subsequently covalently immobilized on alumina chip by Pieters, Liskamp, and coworkers.The study of the binding of fluorescence-tagged lectins to the glycoclusters on the chip revealed the multivalency enhancement of the binding. 

DENDRITIC MOLECULES ON SOLID SUPPORT SOLID-PHASE SYNTHESIS AND APPLICATIONS 

Differences in the extent of this enhancement for different lectins were attributed to the variations in the distance between the binding sites on the lectins. 

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