Dendrobates speciosus

Piperidines, like pyrrolidines, appear to have a very limited distribution in dendrobatid frogs. Piperidine 241D occurs as a major alkaloid in one population of Dendrobates speciosus and as a trace alkaloid in a population of Dendrobates pumilio (1). 2,6-Disubstituted piperidines 225B and 2391 have been detected as trace alkaloids in Dendrobates histrionicus (two populations) and Epipedobates trivittatus (one population), respectively (1). In nondendrobatid frogs, 2,6-disubstituted piperidines have not been detected. 

C. CpHzsN,—, 153°C, mIz 195(65), 152(100). OD. Infrared data(7i). Hq derivative. Alkaloid 195C may prove to represent different compounds in different extracts. Major alkaloid in one population of Dendrobates speciosus minor alkaloid in certain populations of D. leucomelus, D. pumilio, and D. speciosus and in D, reticulatus and Minyobates steyer-marki. Detected in a ranid frog (73),... 

Edwards MW, Daly JW, Myers CW (1988) Akaloids from a Panamanian poison frog, Dendrobates speciosus identification of pumiliotoxin-A and allopumiliotoxin class alkaloids, 3,5-disubstituted indolizidines, 5-substituted 8-methylindolizidines, and a 2-methyl-6-nonyl-4-hydroxypiperidine. J Nat Prod 51 1188-1197 Emsley L, Bodenhausen G (1989) Self-refocusing effect of 270° Gaussian pulses. Applications to selective two-dimensional exchange spectroscopy. J Magn Reson 82 211-221... 

Alkaloid from skin extracts of the Panamanian poison frog Dendrobates speciosus. Also detected as a trace constit. in certain populations of D. pumilio. [(x] + 39 (c, 0.2 in MeOH). 

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