Dendrobates histrionicus Gephyrotoxin

An unusual acetylenic alkaloid, gephyrotoxin, has been isolated from skin extracts of the Colombian frog Dendrobates histrionicus, and it has been shown tobe[lS,3a5,5a5,65(Z),9ai ,10/ ]-dodecahydro-6-(pent-2-en-4-ynyl)pyrrolo[l,2-a]quinoline-l-ethanol (5) by X-ray crystal structure analysis of gephyrotoxin... 

Gephyrotoxins are unique in Nature to amphibians and, indeed, occur only in certain populations of the extremely variable Colombian poison frog, Dendrobates histrionicus (1). Gephyrotoxin might be derived by cyclization of a c/.r-decahydroquinoline having a trans orientation of the... 

Gephyrotoxins. One of the major alkaloids from Dendrobates histrionicus proved to be not a histrionicotoxin but instead a tricyclic alkaloid... 

Daly, J. W., B. Witkop, T. Tokuyama, T. Nishikawa, and I. L. Karle Gephyrotoxins, histrionicotoxins and pumiliotoxins from the neotropical frog Dendrobates histrionicus. Helv. Chim. Acta 60, 1128—1140 (1977). 

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