Dendrimers biological, evaluation

Shukla, S., Wu, G., Chatterjee, M., Yang, W., Sekido, M., Diop, L.A., Muller, R., Sudimack, J.J., Lee, R.J., Barth, R.F., and Tjarks, W. (2003) Synthesis and biological evaluation of folate receptor-targeted boro-nated PAMAM dendrimers as potential agents for neutron capture therapy. Bioconjugate Chem. 14, 158-167. 

Roberts, J.C., Bhalgat, M.K. and Zera, R.T. (1996) Preliminary biological evaluation of polyamidoamine (PAMAM) Starburst dendrimers. J. Biomed. Mater. Res., 30, 53-65. 

Roberts, J.C. Bhalgat, M.K. Zera, R.T. Preliminary biological evaluation of polyamidoamine (PAMAM) star-burst dendrimers. J. Biomed. Mater. Res. 1996, 30, 53-65. Malik, N. Wiwattanapatapee, R. Klopsch, R. Lorenz, K. Frey, H. Weener, J.W. Meijer, E.W. Paulus, W. Duncan, R. Dendrimers relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of l-Labeled polyamidoamine dendrimers in vivo. J. Control. Release 2000, 65, 133-148. 

Electroactive dendrimers are defined as those that contain functional groups capable of undergoing fast electron transfer reactions [85], The combination of specific electron transfer properties of redox active probes with the unique structural properties of dendrimers offers attractive prospects of their exploitation in electrocatalytic processes of biological and industrial importance [86], Further, the interest in dendrimers containing electroactive units also relies on the fact that electrochemistry is a powerful technique to elucidate the structure and purity of dendrimers, to evaluate the degree of electronic interaction of their chemically and/or topologically equivalent or non- equivalent moieties, and also to study their endo- and exo-receptor capabilities [87],... 

Gazumyan A, Mitsner B, Ellestad GA (2000) Novel anti-RSV dianionic dendrimer-like compounds design, synthesis and biological evaluation. Curr Pharm Des 6 525-546... 

Importance Dendrimers (conecdy made) are single molecular entities, which facilitate reproducibility in biological evaluations compared to self-assembled stmctures that are more heterogeneous in size and composition. This aspect may also be of importance from a regulatory perspective. 

Shukla, S. Wu, G. Chatterjee, M. et al.. Synthesis and Biological Evaluation of Folate Receptor Targeted Boronated PAMAM Dendrimers as Potential Agents for Neutron Capture Therapy. Bioconjug. Chem. 2003,14, 158-167. 

Oka, H., Onaga, T., Koyama, T., Guo, C. T., Suzuki, Y., Esumi, Y, Hatano, K., Terunuma, D., and Matsuoka, K. 2009. Syntheses and biological evaluations of carbosilane dendrimers uniformly functionalized with sialyl alpha(2—> 3) lactose moieties as inhibitors for human influenza viruses. Bioorg Med Chem 17(15), 5465-5475. 

A series of mannosylated dendrimers have been prepared and evaluated for their biological properties, in particular as inhibitors of plant lectins.83 Subsequently, mannosylated PAMAM, and a dendrimer based on a 3,5-bis-(2-aminoethoxy)benzoic acid branching unit, have been tested for their ability to inhibit bacterial infection by interfering with the binding of uropathogenic... 

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