Demyelination factors involved

Before determining the chemical factors involved in myelin disorders, it is useful to first recall the morphological particularities of myelin and the Ranvier node, in CNS and PNS, as these are the major targets of demyelination. 

To understand the role of the different constituents of oligodendrocytes, Schwann cells, and myelin, and the cellular interactions, it is necessary to consider each constituent and the abnormalities that occur in experimental models and in human pathology. Each specific compound of myelin, and many factors involved in myeli-nation, can give rise to genetic diseases or autoimmune diseases. There are many animal models and human diseases that help in understanding the demyelination process. 

Other Glial Cell Types and Factors Involved in Myelination and Demyelination in the CNS... 

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