Demeclocycline Carbamazepine

Carbamazepine and tricyclic antidepressants, as well as phenothiazines, opiates, and barbiturates can cause hyponatremia, which would be additive with that produced by demeclocycline. 

Discuss the problems with the administration of demeclocycline post-carbamazepine dosage. 

The administration of carbamazepine results in a decrease in the half-life of demeclocycline. 

The major receptor-mediated adverse effect is water intoxication, which can occur with desmopressin or vasopressin. Many drugs, including carbamazepine, chlorpropamide, morphine, tricyclic antidepressants and NSAIDs, can potentiate the antidiuretic effects of these peptides, while lithium, demeclocycline and ethanol can attenuate the antidiuretic response to desmopressin. Desmopressin and vasopressin should be used cautiously when a rapid increase in extracellular water may impose risks (e.g., in angina, hypertension, and heart failure) and should not be used in patients with acute renal failure. Patients receiving desmopressin to maintain hemostasis should be... 

Similar results were found in 16 other patients taking various combinations of phenytoin, carbamazepine, primidone or phenobarbital. The serum doxycycline levels of almost all of them fell below 0.5 micrograms/mL during the 12 to 24 hour period following their last dose of doxycycline 100 mg. Tetracycline, methacycline, oxytetracycline, demeclocycline and chlortetracycline levels were not significantly affected by these antiepilepties. Other studies confirm this interaction between some barbiturates (amobarbital, pentobarbital, phenobarbital) and doxycycline. ... 

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