Deltorphin antinociception activity

Delta receptors nevertheless mediate some delta agonist induced analgesia, as suggested by reduced DPDPE and deltorphin activity in the DOR mutant after ITH applications [52], or enhanced antinociceptive activity in MOR mutants subjected to CFA inflammation [65]. Delta receptors also depress respiratory neurons in slice preparations [66] and mediate SNC80-evoked convulsions [67]. 

Negri L, Lattanzi R, Tabacco F, Orru L, Severini C, Scolaro B, Rocchi R (1999) Dermorphin and deltorphin glycosylated analogues Synthesis and antinociceptive activity after systemic administration. J Med Chem 42 400-404... 

In vitro antinociception activity of [Dmt( deltorphin B and related peptides... 

While the high affinity for the g-opioid receptor was confirmed in the in vitro pharmacological assay (guinea- pig ileum), in vivo antinociception apparently failed to correlate with high g-opioid receptor activity however, the activity profile of peptide 1 [DMT1] deltorphin B was more closely related to that of the 8- selective opioid peptides 2 (deltorphin B) and 3 (deltorphin C). 

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