Delta receptors adenylate cyclase

Endogenous opioid receptors have been identified, cloned, and sequenced. They are members of the trimeric G-protein-binding superfamily, which are coupled to signal transduction via adenyl cyclase, and to Ca and ion-channel transport. Three major receptor subtypes are known (mu, kappa, and delta). Mu (p) receptor activation results in sedation, euphoria (via dopamine release), analgesia, respiratory depression, and GI dysmoflity. Kappa (k) receptors mediate spinal analgesia, miosis (via acetylcholine... [Pg.1339]

Howlett AC, Champion TM, Wilken GH, Mechoulam R (1990) Stereochemical effects of 11-OH-delta 8-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor. Neuropharmacology 29 161-165... [Pg.73]

Reisine T, Heerding J, Raynor K (1994) The third intracellular loop of the delta receptor is necessary for coupling to adenyl cyclase and receptor desensitization. Regul Pept 54 241-242... [Pg.103]

AD clinical trials, 1257 Addiction, 1207, 1375 Additive, 3983, 3984 A-delta fibers, 1371 Adenocarcinoma, 2421 Adenosine A2A receptor, 2682, 4115 Adenosine monophosphate-activated protein kinase (AMPK), 1304 Adenosine receptor, 946 Adenosine triphosphate (ATP), 3706 Adenylation protein, 51 Adenylyl cyclase, 3327 Adhatoda, 802 Adhatoda vasica, 4095... [Pg.4162]

Big Chemical Encyclopedia