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Delivery tissue-selective

Tissue-selective activation of classical prodrugs Site-specific delivery of ad hoc chemical systems... [Pg.24]

Turning our attention first to alkyl carbamates of cyclic amides, we find interesting attempts to improve the pharmaceutical and pharmacokinetic properties of 5-fluorouracil (8.152, R = H) [194-196], This antitumor agent, while clinically useful, suffers from poor water solubility, unsatisfactory delivery properties and low tissue selectivity. A variety of prodrug candidates were prepared, in particular the alkyl and aryl carbamates presented in Table 8.12. With the exception of the more-lipophilic derivatives, these compounds exhibited somewhat improved water solubility. More importantly, both rectal and oral bioavailability were markedly improved. The activation... [Pg.513]

See other pages where Delivery tissue-selective is mentioned: [Pg.307]    [Pg.342]    [Pg.683]    [Pg.321]    [Pg.37]    [Pg.78]    [Pg.390]    [Pg.421]    [Pg.314]    [Pg.93]    [Pg.549]    [Pg.138]    [Pg.560]    [Pg.561]    [Pg.563]    [Pg.568]    [Pg.269]    [Pg.129]    [Pg.547]    [Pg.98]    [Pg.986]    [Pg.439]    [Pg.359]    [Pg.85]    [Pg.196]    [Pg.800]    [Pg.850]    [Pg.496]    [Pg.168]    [Pg.17]    [Pg.124]    [Pg.294]    [Pg.90]    [Pg.210]    [Pg.929]    [Pg.213]    [Pg.310]    [Pg.449]    [Pg.19]    [Pg.531]    [Pg.533]    [Pg.544]    [Pg.544]    [Pg.227]    [Pg.176]    [Pg.525]    [Pg.528]    [Pg.886]   
See also in sourсe #XX -- [ Pg.568 ]



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Selective tissue selectivity

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