Delivery for Proliferative Vitreoretinopathy Prevention and Treatment

Drug Delivery for Proliferative Vitreoretinopathy Prevention and Treatment 

Duke University Eye Center, Durham, North Carolina, U.S.A. 

Surgery is the primary form of therapy used to manage eyes with retinal detachment and PVR. Epiretinal and occasionally subretinal membranes (Fig. 3) are removed to release retinal traction, followed by reattachment and tamponade with either gas or silicone oil. In a multicenter randomized clinical trial of 340 eyes with 

While surgical techniques and instruments have improved and anatomic success has remained fairly high, functional improvement has been limited. There is hope that 

The ideal drug for treating patients at high risk for PVR, or for use as an adjunct to surgery in established PVR would be one that achieves therapeutic levels in the eye for weeks to months, one that addresses a variety of mechanisms of PVR development, that can be delivered with minimal added surgical risk, and that has few to no ocular or systemic side effects. 

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