Delayed skin maculopapular exanthema

Fig. 1 Methods to study delayed drug hypersensitivity reactions in humans, (a) T cells - mainly from the peripheral blood, but also from tissue sections (skin, kidney), proliferate when exposed to drugs in cell culture. The proliferating cells can be expanded and then cloned by limiting dilutions, and functional and phenotypic analysis performed to evaluate how drugs are stimulatory for T cells and which functions they perform, (b) Immunhistology of skin (and kidney) using antibodies to cell surface and cytokines, etc. the example shows that in a maculopapular exanthema both CD4+ and CD8+ T cells also express perforin...

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