Dehydroquinate synthase

CELLOBIOSE PHOSPHORYLASE CHORISMATE SYNTHASE COBALAMIN ADENOSYLTRANSFERASE 3-DEHYDROQUINATE SYNTHASE... 

The shikimate pathway is common to both plants and microorganisms (Figure 3-3). Shikimate is synthesized from the substrates phosphoewo/pyruvate (3.9) and erythrose 4-phosphate (3.17). These two precursors are derived from glycolysis and the pentose phosphate pathway, respectively, and are condensed to 3-deoxy-D-ara6/ o-heptulosonate 7-phosphate (DAHP 3.18) by the enzyme DAHP synthase. The subsequent steps result in the formation of 3-dehydro-quinate (3.19) by the enzyme 3-dehydroquinate synthase, 3-dehydroshikimate... 

S. L. Rotenberg and D. B. Sprinson, Isotope effects in 3-dehydroquinate synthase and dehydratase. Mechanistic implications, J. Biol. Chem., 253 (1978) 2210-2215. 

Montchamp, J.-L., Peng, J., and Frost, J.W., Inversion of an asymmetric center in carbocyclic inhibitors of 3-dehydroquinate synthase. Examining and exploiting the mechanism for iyn-elimination during substrate turnover, J. Org. Chem., 59, 6999, 1994. 

Roisch and Lingens (88) recently found 3-dehydroquinate synthase (Figure 3, No. 2-altemate nomenclature) and phospho-... 

The first acyclic intermediate, 3-deoxy-D-amZ>//i6>-heptu-losonic acid 7-phosphate (DAHP) (3), is then cyclized by 3-dehydroquinate synthase to 3-dehydroquinate (4), the first cyclic intermediate in the pathway (Dewick, 1989 Knowles, 1989). 

Photoconversion of 118 into cyclitols 119 and 120 has been observed.However only product 119 is formed when 118 is treated with 3-dehydroquinate synthase prompting the question does the enzyme catalyse 118 to 119 or just provide a conformational tmplate to prevent formation of 120 ... 

The isolation and characterization of several new isomers of (-) quinic acid, obtained by boiling quinic acid in a mixture of acetic and sulfuric acids in order to obtain reference materials for identifying components of roasted coffee, has been achieved/ Quinic acid has also been used in a short synthesis of compound (43), a phosphonate analogue of a reactive intermediate formed during 3-dehydroquinate synthase (DHQ synthase)-catalysed conversion of 3-deoxy-D-arabjno-heptulosonic acid-7-phosphate (DHAP) to 3-dehydroquinate (DHQ), as an irreversible inhibitor of DHQ synthase/ ... 

A one pot enzymatic synthesis of (6/ )- and (65 -fluoroshikimic acid from erythrose 4-phosphate and both isomers of 3-fluorophosphoenolpyruvate in the presence of 3-deoxy-D-ara mo-heptulosonic acid 7-phosphate synthase, followed by treatment with 3-dehydroquinate synthase and dehydroquinase simultaneously, then finally shikimate dehydrogenase has been described. ... 

Individual common pathway enzymes become impediments to increased carbon flow due to their inability to convert substrate into product at a rate sufficiently rapid to avoid cytoplasmic accumulation and subsequent export of the substrate into the culture medium." 3-Dehydroquinate synthase and shikimate dehydrogenase are both impediments to increased carbon flow that result, respectively, in accumu-... 

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