Dehydroquinate pathway synthesis

The well-known cytoplasmic shikimate pathway is important to aromatic amino acid synthesis. It takes a long metabolic pathway to reach to an aromatic amino acid from D-glucose. Two metabolic intermediates, phosphoenolpymvate from the glycolytic pathway and D-erythrose-4-phosphate from the pentose-phosphate pathway, must combine to form 3-deoxy-7-phospho-D-arabinoheptulosonate before formation of 3-dehydroquinate (Fig. 13.4). Thus, there are still several barriers difficult to overcome in the already existing technologies of shikimate fermentation from D-glucose (Draths et al. 1999). 

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