Dehydron Clusters and Disordered Regions

In this chapter we identify functional indicators of PDB-reported soluble proteins with clusters of dehydrons. Such regions, rich in structural vulnerabilities, may be characterized as belonging to a twilight zone between order and native disorder [4], This characterization is already suggested by a strong correlation between wrapping of intramolecular hydrogen bonds (p) and propensity for structural disorder (/d), as shown in Fig. 5.1. The correlation reveals that the inability to exclude 

Fernandez, Transformative Concepts for Drug Design Target Wrapping, 59 

5 Under-Wrapped Proteins in the Order-Disorder Twilight 

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