Enzymes degradation and

Le Maitre CL, Freemont AJ, Hoyland JA (2004) Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc. J Pathol 204(l) 47-54... 

The torsion angles around the bonds of the sugar-phosphate DNA backbone are of decisive importance for the secondary structure of DNA as well as for base-base recognition. [44] For antisense agents to be effective inhibitors of protein expression in vivo, they have to resist the action of DNA-degrading enzymes and bind to their... 

The aim of this study was to find proof that the Maillard reaction can take place in demineralized dentin. Markers for the initial and advanced Maillard reaction as well as physiological cross-links were investigated after incubation of bovine dentin with glucose. Changes in susceptibility to protein-degrading enzymes and in fluorescence specific for the reaction were additionally measured. 

Matsumura S, Tomizawa N et al. (1999) Novel poIy(vinyI aIcohoI)-degrading enzyme and the degradation mechanism. Macromolecules 32 7753-7761... 

Qiu, W. Q. and Folstein, M. F. (2006). Insulin, insulin-degrading enzyme and amyloid-beta peptide inn Alzheimer s disease Review and hypothesis. Neurobiol. Aging 27,190-198. 

Many enzymes that act on DNA are involved in processes other than DNA synthesis. They include DNA repair enzymes, DNA degradation enzymes, and DNA recombination enzymes. 

Ishida Y. and Leal S. (2002) Cloning of putative odorant-degrading enzyme and integumental esterase cDNAs from the wild silkmoth, Antheraea polyphemus. Insect Biochem. Mol. Biol. 32, 1775-1780. 

St. Leger, R. J., Joshi, L., and Roberts, D. (1998). Ambient pH is a major determinant in the expression of cuticle-degrading enzymes and hydrophobin by Metarhizium anisopliae. Applied and Environmental Microbiology, 64, 709-713. 

Lipids have several important functions in animal cells, which include serving as structural components of membranes and as a stored source of metabolic fuel (Griner et al., 1993). Eukaryotic cell membranes are composed of a complex array of proteins, phospholipids, sphingolipids, and cholesterol. The relative proportions and fatty acid composition of these components dictate the physical properties of membranes, such as fluidity, surface potential, microdomain structure, and permeability. This in turn regulates the localization and activity of membrane-associated proteins. Assembly of membranes necessitates the coordinate synthesis and catabolism of phospholipids, sterols, and sphingolipids to create the unique properties of a given cellular membrane. This must be an extremely complex process that requires coordination of multiple biosynthetic and degradative enzymes and lipid transport activities. 

The endosome fuses with a lysosome containing a large number of degradative enzymes and a low pH on the inside. 

Because the reaction is degradative, it requires a starch chain, and the product of a single event is a-Glc 1-P and a starch chain that has had one or more glucosyl residues removed. It is, therefore, not surprising that the reaction in the reverse synthetic direction also requires a starch chain or so-called primer. The primer hypothesis for the synthesis of polysaccharide was, thus, developed from an enzyme that was actually a degradative enzyme and not a synthetic enzyme. Nevertheless, the primer-dependent mechanism has been incorrectly assumed for the biosynthesis of starch for over 60 years. 

Sulfated galactans may interact with numerous regulatory proteins affording inhibition of complement activation, of tumor cell adhesion to P-selectin, of several matrix-degrading enzymes, and so on.668-670 These features depend strongly on the... 

Beside adhesion per se, tumor cell interactions with ECM components influence motility, invasiveness and many other important aspects of the metastatic tumor cell phenotype. Tumor cell motility and adhesion are, in fact, closely linked, thus implicating a role for tumor cell adhesion in invasion. Indeed, tumor cell invasion has been proposed to represent a three step process, involving tumor cell adhesion, release of ECM degrading enzymes and tumor cell... 

Vacca, A., Ribatti, D., lurlaro, M., Albini, A., Minischetti, M., Bussolino, R, Pellegrino, A., Ria, R., Rusnati, M., Presta, M., Vincenti, V., Persico, M. G. and Dammacco, R (1998). Human lymphoblastoid cells produce extracellular matrix-degrading enzymes and induce endothelial cell proliferation, migration, morphogenesis, and angiogenesis. Int. J. Clin. Lab. Res. 28, 55-68. 

Bonnin, E. et al., Aspergillus niger 1-1472 and Pycnoporus cinnabarinus MUCEL 39533, selected for the biotransformation of ferulic acid to vanillin, are also able to produce cell wall polysaccharide-degrading enzymes and feruloyl esterases, Enzyme Microb. Technol, 28, 70, 2001. 

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