Definition and Nomenclature of C-Glycosides

Carbohydrates have long been a source of scientific interest due to their abundance in nature and the synthetic challenges posed by their polyhydroxylated structures. However, the commercial use of carbohydrates has been greatly limited by the hydrolytic lability of the glycosidic bond. With the advent of C-glycosides, this limitation promises to be overcome thus paving the way for a new generation of carbohydrate-based products. 

Properties, Anomeric Effects, H-Bonding Abilities, Stabilities and Conformations 

Stability Cleaved by Acid and Enzymes Stable to Acid and Enzymes 

Perhaps the major difference between C and O-glycosides is found within chemical reactivities. Not only are C-glycosides absent of anomeric effects, they are also stable to acid hydrolysis and are incapable of forming hydrogen bonds. 

In an NMR study of the conformations of C-glycofuranosides and C-glycopyranosides, Brakta, et al.,7 demonstrated that the 1Hi--2 coupling constants were limited in their abilities to define conformations. However, the 

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