Heart failure deferiprone

Since circulating deferiprone-iron complexes can easily dissociate, deferiprone can redistribute iron in the body (14). Although this might theoretically lead to the precipitation or aggravation of heart failure (14), no such cases have as yet been reported. 

Cardiovascular A severe cardiomyopathy with congestive heart failure has been reported after withdrawal of deferiprone for severe arthritis [29 ]. 

Another patient, with suspected deferiprone-related heart failure, had acute severe bilateral arthritis of the knees 6 weeks after starting deferiprone, necessitating drug withdrawal [29 ]. 

Aqodad N, Lor6al O, Erdtman L, Brissot P, Guyader D. Fatal congestive heart failure with deferiprone. Gastroenterol Clin Biol 2008 32(6-7) 656-7. 

Porter JB, Wood J, Olivieri N, Vichinsky EP, Taher A, Neufeld E, et al. Treatment of heart failure in adults with thalassemia major response in patients randomised to deferoxamine with or without deferiprone. J Cardiovasc Magn Reson 2013 15 38. 

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