Phenobarbital Deferasirox

Deravirdine (Rescnptor) [Antiretroviral/NNRTI] Uses HIV Infxn Action Nonnucleoside RT inhibitor Dose 400 mg PO tid Caution [C, ] CDC recommends HIV-infected mothers not to breast-feed (transmission risk) w/ renal/hepatic impair Contra Use w/ drugs dependent on CYP3A for clearance (Table VI-8) Disp Tabs SE Fat redistribution, immune reconstitution synd, HA, fatigue, rash, T transaminases, N/V/D Interactions T Effects W/ fluoxetine T effects OF benzodiazepines, cisapride, clarithromycin, dapsone, ergotamine, indinavir, lovastatin, midazolam, nifedipine, quinidine, ritonavir, simvastatin, terfena-dine, triazolam, warfarin effects W/ antacids, barbiturates, carbamazepine, cimetidine, famotidine, lansoprazole, nizatidine, phenobarbital, phenytoin, ranitidine, rifabutin, rifampin effects OF didanosine EMS Use of benzodiazepines and CCBs should be avoided may cause a widespread rash located on upper body and arms OD May cause an extension of nl SEs symptomatic and supportive Deferasirox (Exjade) [Iron Chelator] Uses Chronic iron overload d/t transfusion in pts >2 y Action Oral iron chelator Dose Initial 20 mg/kg... 

Deferasirox did not alter the pharmacokinetics of digoxin. Food increases the bioavailability of deferasirox, and it should be taken on an empty stomach. The use of deferasirox with aluminium antacids is not recommended. Rifampicin, phenobarbital and pheny-toin are predicted to increase the metabolism of deferasirox, and, until more is known, concurrent use should be monitored. Based on in vitro data, deferasirox might inhibit the metabolism of CYP2C8 substrates like paclitaxel and repaglinide. Hydroxycar-bamide does not alter deferasirox metabolism. 

Deferasirox metabolism is predicted to be increased if it is given with UGT enzyme inducers such as rifampicin (rifampin), phenobarbital or phenytoin because deferasirox is metabolised principally by glucuronida-tion. Pending the results of a drug-interaction study the UK manufacturer recommends that the efficacy of deferasirox (serum ferritin levels) should be monitored if these drugs are used together with deferasirox, and when they are stopped, and the dose of deferasirox adjusted if necessary. ... 

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See also in sourсe #XX -- [ ]

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