Decylmethyl sulfoxide, effect

In addition to the esters of saturated and unsaturated fatty acids, azone and decylmethyl sulfoxide are also very effective in enhancing the skin permeability of drugs (Table II and Figure 6). Results appear to suggest the possible existence of a relationship between the skin permeability enhancement of a drug, molecular structure of the drug, as well as the type of enhancer used. The skin permeability can be further improved by incorporating... 

As the concentration of enhancer in the adhesive layer increases by 5 folds, the skin permeation rate of progesterone across the intact skin increase substantially for capric acid and decyl-methyl sulfoxide, but not for azone and oleic acid. The delipid-ization of stratum corneum significantly affects the enhancing effect of azone on the skin permeation rate of progesterone, but not on that of decylmethyl sulfoxide. The effect of delipidization on the enhancing capacity of capric acid and oleic acid is relatively small (Table V). 

Tables VI and VII ). On the other hand, capric acid and decylmethyl sulfoxide showed a dual effect on the hydrophilic protein gel and also on the lipophilic fatty matrix. In the case of capric acid, the overall enhancement in the permeation of progesterone was increased by 354%, in which the protein gel pathway and fatty matrix pathway contribute approximately equally (with enhancement factor of 15.3 vs. 13.0). In the case of decylmethyl sulfoxide, the overall enhancement was improved by 515% (40.2 vs. 7.8).

Choi, H.K. Flynn, G.L. Atnidon, G.L. Transdermal delivery of bioactive peptides the effect of n-Decylmethyl Sulfoxide, pH, and inhibitors on enkephalin metabolism and transport. Pharm. Res. 1990, 7, 1099-1106. 

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