Decosahexaenoic acid

Elucidation of the physiological role of arachidonic acid 13 and other polyunsaturated fatty acids, particularly the role of all Z-4,7,10,13,16,19-decosahexaenoic acid 14, found in brain, required the corresponding stable-isotope labelled material1011. The deuteriated phosphonium salt 15, the key intermediate used in the synthesis of title compound 16 (equation 8), has been prepared in 19% overall yield12 starting with ethanol-D6 (equation 7). 

Lim, G.P., Calon, F., Morihara, T., et al. (2005) A diet enriched with the omega-3 fatty acid decosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J. Neurosci., 23, 3032-3040. 

Figure 9. Aldehydes derived from autoxidized decosahexaenoic acid.

De-Caterina R, Cybulsky MI, CUnton SK. Gimbrone MA, Libby P. The omega-3 fatty acid decosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins im human endothial cell. Arteriosclerosis Thromb Vase Biol 1994 14(11) 1829-1836. 

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