Deconvolution mutational SURF

Iterative deconvolution Recursive deconvolution Subtractive deconvolution Positional scanning/indexing Mutational surf other methods... 

Several other deconvolution methods have been reported. Orthogonal libraries (168), subtractive deconvolution (169), omission libraries (170), bogus coin deconvolution (171), deletion synthesis deconvolution (172), and mutational SURF (Synthetic... 

ITERATIVE DECONVOLUTION RECURSIVE DECONVOLUTION SUBTRACTIVE DECONVOLUTION POSITIONAL SCANNING/INDEXING MUTATIONAL SURF OTHER METHODS... 

The mutational SURF method was presented by Freier et al. [75] and was intended as a refinement of other existing deconvolution techniques. While the only reported example deals with virtual oligonucleotide libraries, the technique looks promising and useful also for real small-organic-molecule libraries. 

Freier et al. [75] showed that mutational SURF (synthetic unrandomization of randomized fragments) improves the quality of the selected structures obtained from any deconvolution technique. The structure of this approach, as applied to the above-mentioned virtual example, is depicted in Figure 11. 

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