Decomposition thymidine hydroperoxides

The lifetimes of the 9 main thymidine hydroperoxides 5-7 that were determined in pure aqueous solutions at 37 °C were found to vary from 1 h for the two trans diastereomers of 6-hydroperoxides (Table 1) to several weeks for 5-(hydroperoxymethyl)-2 -deoxyuridine. It may be added that the cis diastereomers are more stable than the trans homologues, irrespective of the pair of diastereomeric hydroperoxides. Interestingly, at neutral or slightly acidic pH values a specific hydrolytic decomposition pathway was observed for the two classes of hydroxyhydroperoxides. Thus, it was found that the trans and... 

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