Dative bond with thiols

Figure 9.60 Many different thiol-containing linkers can be used to prepare water-soluble QDs. The monothiol compounds suffer from the deficiency of being easily oxidized or displaced off the surface, thus creating holes for potential nonspecific binding. The dithiol linkers are superior in this regard, as they form highly stable dative bonds with the semiconductor metal surface that do not get displaced. The PEG-based linkers are especially effective at creating a biocompatible surface for conjugation with biomolecules.

Thiol-containing molecules can interact with metal ions and metal surfaces to form dative bonds. Dative bonds also are known as coordinate covalent bonds. They differ from normal... 

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