Data for Nucleophilic Heteroaromatic Substitution

Appendix Kinetic Data for Nucleophilic Heteroaromatic Substitution 

Interpretations may be ephemeral, but experimental data are permanent. To conserve space, the collection of kinetic data presented here is confined to studies which include the determination of at least one activation parameter. For kinetic studies reporting rate constants at a single temperature the following references should be consulted 21, 23, 27, 29(b), 30, 31, 33-39, 44, 46, 48, 52, 81, 86, 92, 96, 99, 141, and 142, as well as some of the tables in this review. Among the excluded studies, those involving catalytic phenomena are especially worthy of mention. 

The heterocycles have been arranged in the following sequence six-membered rings (aza- and polyaza-benzenes, aza- and polyaza-naphthalenes, etc.) followed by five-membered rings. Derivatives are arranged in alphabetical order according to the substituents. 

In the second and third columns, the reagent and solvent, respectively, are entered. 

Rate constants (fifth column) usually correspond to one of the temperatures reported in the original papers and may be either experimentally determined values or those calculated from the activation parameters. In the preparation of the present review, the author has normalized a number of rate constants at arbitrary temperatures to permit direct comparisons with other data these normalized values and temperatures are tabulated (in italics) with the hope that they will offer additional useful information. The rate constants are usually expressed in liter x mole x sec when the values are followed by the symbol (A i) the units are sec. and dH are in kcal/mole JS is in eu. 

---

Vn. Appendix Kinetic Data for Nucleophilic Heteroaromatic Substitution. 359... 

---