Darzens glycidic ester

Benzilic acid rearrangement Benzoin reaction (condensation) Blanc chloromethylation reaction Bouveault-Blanc reduction Bucherer hydantoin synthesis Bucherer reaction Cannizzaro reaction Claisen aldoi condensation Claisen condensation Claisen-Schmidt reaction. Clemmensen reduction Darzens glycidic ester condensation Diazoamino-aminoazo rearrangement Dieckmann reaction Diels-Alder reaction Doebner reaction Erlenmeyer azlactone synthesis Fischer indole synthesis Fischer-Speior esterification Friedel-Crafts reaction... [Pg.1210]

Darzens glycidic ester condensation generally involves the condensation of an aldehyde or ketone 2 with the enolate of an a-halo ester 1 which leads to an a,P-epoxy ester (a glycidic ester) (3). Thus the reaction adds two carbons to the electrophile however, the reaction has been primarily developed as a one-carbon homologation method. That is, subsequent to the condensation, the ester is saponified and decarboxylation ensues to give the corresponding aldehyde or ketone 5.2... [Pg.15]

Rosen, T. Darzens Glycidic Ester Condensation In Comprehensive Organic Synthesis Trost, B. M. Fleming, I., Eds. Pergamon Oxford, 1991, vol. 2, pp 409-439. (Review). [Pg.184]

Myers, B. J. Darzens Glycidic Ester Condensation In Name Reactions in Heterocyclic Chemistry, Li, J. J. Corey, E. J., Eds. Wiley Sons Hoboken, NJ, 2005, 15—21. (Review). [Pg.184]

Darzens Condensation (Darzens-Claisen Reaction, Darzens Glycidic Ester Condensation)... [Pg.198]

Dalton s law of partial pressures, 12 Darzens glycidic ester condensation, 906J, 907... [Pg.1172]

Glycidic esters are prepared by the reaction of an aldehyde or ketone with an a-haloester in the presence of base (sodium ethoxide, sodamide, finely divided sodium or potassium t-butoxide) (the Darzens glycidic ester condensation). [Pg.598]

An illustrative example of oxirane formation by the action of alkali on a / -halohydrin is to be found in the reaction sequence involved in the Darzens glycidic ester synthesis (Section 5.7.6, p. 598). Three target molecules, namely 2-phenylaziridine (4), methyl (S)-thiiranecarboxylate (5) and cyclooctene sulphide (6), are selected here to exemplify this intramolecular cyclisation reaction type. [Pg.1128]