Dalbergia cochinchinensis

A modification to method C devised by Jake Cha has enabled the synthesis of 2-substituted benzodihydrofurans, while in route to phenolic constituents from Dalbergia cochinchinensis such as 49.26 For example, addition of phenyl lithium to 2-OBoc-4,5-bis-methoxybenzaldehyde 47 followed by the addition of iodomethyl Grignard proceeds to the benzodihydrofuran 48 in a 60% yield (Fig. 4.25). 

FIGURE 4.25 Strategy for phenol 49 from Dalbergia cochinchinensis. 

Pathak, V. et al., Antiandrogenic phenolic constituents from Dalbergia cochinchinensis. Phytochemistry, 46, 1219, 1997. 

Hydroxy-6,7- dimethoxydalbergiquinol Dalbergia cochinchinensis (Fabaceae) AND-R antagonist [antiandrogen]... 

Svasti J, Srisomsap C, Techasakul S, Surarit R (1999) Dalchochinin-S -O-ZJ-D-Glu-coside and Its /J-Glucosidase Enzyme from Dalbergia cochinchinensis. Phytochemistry 50 739... 

Svasti, J., Srisomsap, C., Techasakul, S. et al. (1999). Dalcochinin-8 -0-p-D-glucoside and its p-glucosidase enzyme from Dalbergia cochinchinensis. Phytochemistry, 50, 739-743. 

Donnelly DMX, Nangle BJ, Prendergast JP, O Sullivan AM 1968 Dalbergia species—5. Isolation of R-5-O-methyllatifolin from Dalbergia cochinchinensis Pierre. Phytochemistry 7 647-649... 

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