Daily health endpoint

The panel smdies of Delfino et al. (2008, 2009) measured pollutants inside and outside the Los Angeles homes of non-smoking elderly subjects with a history of coronary artery disease. Health endpoints examined included various markers of inflammation, platelet activation, and anti-oxidant capacity. Pollutants included hourly concentrations of EC, BC, primary OC, SOA, particle number, CO, ozone, and NO2, and daily size-fractionated PM. Thus these two studies had very good subject exposure and included a large number of health-relevant pollutants. 

Methods for toxicological safety assessments are multiple and varied - some are more reliable than others, some more radical than others, but all are important. Their nature greatly depends on their endpoints, namely, the degree of practical safety they attempt to attain. Unfortunately, the true validity of these methods can only be assessed retrospectively, that is to say, by the record of cases of health impairment they were able to prevent over a reasonable period of time. Because of this and the uncertainty inherent in any extrapolation technique, the final products expressed in numerical form can only be considered as opinions. Some important toxicological opinions presented in numerical form are the LD50 the quantitative risk assessments, the threshold limit values (TLV), and the acceptable daily intakes (ADIs). 

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